Categories: Health

US docs successfully transplant pig hearts in two brain-dead humans in major breakthrough

<p>
 A team at NYU Langone Health successfully transplanted two genetically engineered pig hearts into recently brain-dead humans in June and July, marking the latest advances toward addressing the nationwide organ shortage and developing a clinical protocol that would provide an alternative supply of organs for people with life-threatening heart disease, according to a press statement by the New York Institute. </p>
<p>
The surgeries, known as xenotransplants, were performed on Thursday, June 16, 2022, and Wednesday, July 6, 2022, at NYU Langone's Tisch Hospital. <a href="https://nyulangone.org/doctors/1356367676/nader-moazami" rel="nofollow">Nader Moazami, MD</a>, surgical director of<a href="https://nyulangone.org/locations/nyu-langone-transplant-institute/heart-transplantation" rel="nofollow"> heart transplantation</a> at the <a href="https://nyulangone.org/locations/nyu-langone-transplant-institute/heart-transplantation" rel="nofollow">NYU Langone Transplant Institute</a>, led the investigational procedures using hearts procured from a facility hundreds of miles away and transplanted into recently deceased donors maintained on ventilator support.</p>
<p>
The transplant surgeries were performed over several hours and heart function was monitored for three days. The first heart xenotransplant concluded on Sunday, June 19, 2022, and the second on Saturday, July 9, 2022. No signs of early rejection were observed in either organ and the hearts functioned normally with standard post-transplant medications and without additional mechanical support.</p>
<p>
The hearts were procured from pigs that had 10 genetic modifications, including 4 porcine gene "knockouts" to prevent rejection and abnormal organ growth as well as 6 human transgenes ("knock-ins") to promote expression of proteins that regulate important biologic pathways that can be disrupted by incompatibilities between pigs and humans. No other investigational devices or medications were used in this NYU Langone Health study. The procurement, transport, transplant surgery, and immunosuppression were aligned with current clinical standards used in heart transplantation.</p>
<p>
"Our goal is to integrate the practices used in a typical, everyday heart transplant, only with a nonhuman organ that will function normally without additional aid from untested devices or medicines," said Dr. Moazami. "We seek to confirm that clinical trials can move ahead using this new supply of organs with the tried-and-true transplant practices we have perfected at the NYU Langone Transplant Institute."</p>
<p>
Alex Reyentovich, MD, medical director of heart transplantation and director of the NYU Langone Advanced Heart Failure program, said these latest advances in xenotransplantation move the field closer to realizing a new supply of organs for those facing life-threatening disease.</p>
<p>
"These are the first steps in developing a deep understanding of the mechanical, molecular, and immunologic aspects of xenoheart transplantation and the feasibility of utilizing standard clinical practice and tools to do so," said Dr. Reyentovich.</p>

IN Bureau

Recent Posts

Hamburg to host India Week 2025 with 70+ events, celebrating bilateral partnership

The city of Hamburg in Germany is set to host the 11th edition of India…

25 minutes ago

Iran’s centrifuge production sites hit by Israeli strikes, IAEA confirms

The International Atomic Energy Agency (IAEA) has confirmed that two Iranian centrifuge production facilities, TESA…

2 hours ago

Paank condemns harassment of Nadia Baloch in Hudda Jail, links ordeal to state repression of Mahrang Baloch

The human rights department of the Baloch National Movement (BNM), Paank, has strongly condemned the…

3 hours ago

INS Arnala, India’s first indigenous Anti-Submarine Shallow Water Craft, commissioned into Navy

In a major boost to India's coastal defence capabilities, the Indian Navy on Wednesday commissioned…

4 hours ago

UN Rights Chief flags China over Tibet, Xinjiang abuses; calls for release of detainees and legal reform

Volker Turk, the UN High Commissioner for Human Rights, on June 17 expressed concern over…

4 hours ago

G7 Canada: PM Modi highlights India’s 4A approach to energy security, hails AI as “critical tool” to boost efficiency, stresses need for green initiatives

Prime Minister Narendra Modi addressed the G7 Outreach Session on the theme 'Energy Security: diversification,…

7 hours ago