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There is &ldquo;consistent strong evidence&rdquo; that SARS-CoV-2 spreads by airborne transmission, according to a path-breaking study published in the reputed British medical journal The Lancet.</p>
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&ldquo;Although other routes can contribute, we believe that the airborne route is likely to be dominant. The public health community should act accordingly and without further delay,&rdquo; the study by six experts from the UK the US and Canada concludes.</p>
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The study points out that it is a scientific error to use lack of direct evidence of SARS-CoV-2 in some air samples to cast doubt on airborne transmission while overlooking the quality and strength of the overall evidence base.</p>
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The team of experts, led by the University of Oxford&#39;s Trish Greenhalgh, reviewed published research and identified 10 streams of evidence to support the predominance of the airborne route.</p>
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First, superspreading events account for substantial SARS-CoV-2 transmission; indeed, such events may be the pandemic&#39;s primary drivers.</p>
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Detailed analyses of human behaviours and interactions, room sizes, ventilation, and other variables in choir concerts, cruise ships, slaughterhouses, care homes, and correctional facilities, among other settings, have shown patterns&mdash;eg, long-range transmission and overdispersion of the basic reproduction number (R0), discussed below&mdash;consistent with airborne spread of SARS-CoV-2 that cannot be adequately explained by droplets or fomites.</p>
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The high incidence of such events strongly suggests the dominance of aerosol transmission.</p>
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Second, long-range transmission of SARS-CoV-2 between people in adjacent rooms but never in each other&#39;s presence has been documented in quarantine hotels.</p>
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Historically, it was possible to prove long-range transmission only in the complete absence of community transmission.</p>
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Third, asymptomatic or presymptomatic transmission of SARS-CoV-2 from people who are not coughing or sneezing is likely to account for at least a third, and perhaps up to 59%, of all transmission globally and is a key way SARS-CoV-2 has spread around the world, supportive of a predominantly airborne mode of transmission. Direct measurements show that speaking produces thousands of aerosol particles and few large droplets, which supports the airborne route.</p>
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Fourth, transmission of SARS-CoV-2 is higher indoors than outdoors and is substantially reduced by indoor ventilation.</p>
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Both observations support a predominantly airborne route of transmission.</p>
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Fifth, nosocomial infections have been documented in health-care organisations, where there have been strict contact-and-droplet precautions and use of personal protective equipment (PPE) designed to protect against droplet but not aerosol exposure.</p>
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Sixth, viable SARS-CoV-2 has been detected in the air. In laboratory experiments, SARS-CoV-2 stayed infectious in the air for up to 3 h with a half-life of 1&middot;1 h.</p>
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Viable SARS-CoV-2 was identified in air samples from rooms occupied by COVID-19 patients in the absence of aerosol-generating health-care procedures and in air samples from an infected person&#39;s car.</p>
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Although other studies have failed to capture viable SARS-CoV-2 in air samples, this is to be expected. Sampling of airborne virus is technically challenging for several reasons, including limited effectiveness of some sampling methods for collecting fine particles, viral dehydration during collection, viral damage due to impact forces (leading to loss of viability), reaerosolisation of virus during collection, and viral retention in the sampling equipment.</p>
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Measles and tuberculosis, two primarily airborne diseases, have never been cultivated from room air.</p>
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Seventh, SARS-CoV-2 has been identified in air filters and building ducts in hospitals with COVID-19 patients; such locations could be reached only by aerosols.</p>
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Eighth, studies involving infected caged animals that were connected to separately caged uninfected animals via an air duct have shown transmission of SARS-CoV-2 that can be adequately explained only by aerosols.</p>
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Ninth, no study to our knowledge has provided strong or consistent evidence to refute the hypothesis of airborne SARS-CoV-2 transmission. Some people have avoided SARS-CoV-2 infection when they have shared air with infected people, but this situation could be explained by a combination of factors, including variation in the amount of viral shedding between infectious individuals by several orders of magnitude and different environmental (especially ventilation) conditions.</p>
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Individual and environmental variation means that a minority of primary cases (notably, individuals shedding high levels of virus in indoor, crowded settings with poor ventilation) account for a majority of secondary infections, which is supported by high-quality contact tracing data from several countries.</p>
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Wide variation in respiratory viral load of SARS-CoV-2 counters arguments that SARS-CoV-2 cannot be airborne because the virus has a lower R0 (estimated at around 2&middot;5)&nbsp; than measles (estimated at around 15), especially since R0, which is an average, does not account for the fact that only a minority of infectious individuals shed high amounts of virus. Overdispersion of R0 is well documented in COVID-19.</p>
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Tenth, there is limited evidence to support other dominant routes of transmission&mdash;ie, respiratory droplet or fomite.</p>
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Ease of infection between people in close proximity to each other has been cited as proof of respiratory droplet transmission of SARS-CoV-2. However, close-proximity transmission in most cases along with distant infection for a few when sharing air is more likely to be explained by dilution of exhaled aerosols with distance from an infected person.</p>
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The flawed assumption that transmission through close proximity implies large respiratory droplets or fomites was historically used for decades to deny the airborne transmission of tuberculosis and measles.</p>
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This became medical dogma, ignoring direct measurements of aerosols and droplets which reveal flaws such as the overwhelming number of aerosols produced in respiratory activities and the arbitrary boundary in particle size of 5 &mu;m between aerosols and droplets, instead of the correct boundary of 100 &mu;m.</p>
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It is sometimes argued that since respiratory droplets are larger than aerosols, they must contain more viruses. However, in diseases where pathogen concentrations have been quantified by particle size, smaller aerosols showed higher pathogen concentrations than droplets when both were measured.</p>
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Public health measures that fail to treat the virus as predominantly airborne leave people unprotected and allow the virus to spread, according to the six experts including Jose-Luis Jimenez, a chemist at the Cooperative Institute for Research in Environmental Sciences (CIRES) and the University of Colorado Boulder.</p>
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&quot;The evidence supporting airborne transmission is overwhelming, and evidence supporting large droplet transmission is almost non-existent,&quot; Jimenez said. &quot;It is urgent that the World Health Organization and other public health agencies adapt their description of transmission to the scientific evidence so that the focus of mitigation is put on reducing airborne transmission.&quot;</p>
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