Health

Can Espresso coffee help prevent Alzheimer’s disease?

Researchers at the University of Verona in Italy have carried out lab tests that show Espresso coffee prevents the aggregation of the troublesome tau protein which leads to the brain-wasting Alzheimer’s disease in humans.

In a study conducted by the Italian team, both a complete espresso extract as well as various compounds isolated from the drink including caffeine, trigonelline and genistein were tested in lab dishes to see how they interact with tau protein tangles known as fibrils which are found in Alzheimer’s patients.

It was found that caffeine and genistein prevented tau protein clumps known as fibrils from forming long strands. This also prevented them from weaving themselves into the larger sheets that disrupt the functioning of the brain resulting in memory loss and the ability to think. It also rendered the fibrils non-toxic and took away their ability to act as seeds and spread to other cells.

Caffeine was further shown to bind to existing tau fibrils which could open the door to further investigation of using the compound either as a therapeutic or a potential test for the presence of tau, according to the researchers.

While caffeine and genistein had the ability to keep the fibrils short, the full espresso extract had the biggest impact on tau. Because many of the compounds in coffee can cross the blood-brain barrier, the researchers believe that simply drinking espresso coffee may provide some of the benefits seen in the study.

“Based on the bioavailability of coffee components in the brain, and on the results of our study, we expect that moderate coffee consumption may provide a sufficient amount of bioactive molecules to act separately or synergistically as modulators of tau protein aggregation and toxicity,” the Italian researchers have stated.

However, they admit that further research will be required to see if the tests, which were conducted both on the isolated compounds and on live cells in lab dishes, will carry over to studies in animals and humans.

The study which has been published in the Journal of Agricultural and Food Chemistry.

IN Bureau

Recent Posts

Balochistan: Medical students protest campus closure, security crackdown

Students at the Bolan Medical College (BMC) in Balochistan's Quetta entered the 27th day of…

1 minute ago

Climate change, health risks escalate amid surge in PoGB deforestation

The intensifying cutting of trees for firewood in Pakistan-occupied Gilgit-Baltistan (PoGB) is not only worsening…

1 hour ago

India’s retired judges, bureaucrats call for “immediate end” to attacks on minorities in open letter to Bangladesh

A group of retired judges, bureaucrats, Army officials and other civil society members have penned…

2 hours ago

Israel, Slovakia sign historic USD 582 million deal to boost Air Defense capabilities

Israel and Slovakia signed a 2 billion shekel (USD 582 million) agreement on Monday to…

2 hours ago

Pakistan: Protests continue in Kurram over road closures amid crisis

Protests against the prolonged road closures in Kurram persisted on Sunday, as residents held a…

3 hours ago

Sikyong Penpa Tsering successfully concludes key engagements in US, strengthening Tibetan cause

Sikyong Penpa Tsering, the political leader of the Central Tibetan Administration (CTA), has successfully concluded…

3 hours ago